Displaying 151 - 175 of 575
Cytokeratin 18 (CK 18), a 45kDa protein, belongs to the acidic type of cytokeratins, and is typically expressed in simple, nonstratified epithelia. However, CK 18 is also expressed in basal and superficial cells of transitional epithelium, as well…
Immunohistochemistry (IHC)
Cytokeratin 19 (CK19) is a member of the type I acidic subfamily of keratins. It is expressed in various different human tissues. CK19 labels ductal and glandular epithelia, prostatic epithelia, and non-keratinizing squamous epithelia. This antibody…
Immunohistochemistry (IHC)
Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel cell carcinomas, and frequently in adenocarcinomas of the stomach, bile system and pancreas. CK7/…
Immunohistochemistry (IHC)
D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low differentiated squamous cell carcinoma and adenocarcinoma. It labels mesothelioma, and epithelial…
Immunohistochemistry (IHC)
Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 distinguishes between lung and breast epithelium that stain positive, and…
Immunohistochemistry (IHC)
Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are tested together, and ATM is tested with p53).Disease…
FISH
Available as global test only. Markers are CD3, CD5, CD19, CD20, CD22, CD43, CD45, CD79b, and CD81 (9 markers).
Flow Cytometry
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD3, CD5, CD19, CD22, CD36, CD43, CD45…
Flow Cytometry
The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-small cell lung carcinoma (NSCLC). High levels of intratumor cMET expression have been associated…
Immunohistochemistry (IHC)
In situ hybridization for detection of cytomegalovirus (CMV) RNA.
In Situ Hybridization (ISH)
Cytomegalovirus (CMV) is an opportunistic pathogen infecting lung, kidney, gut and other organs in situations where an individual is immunologically immature, such as the fetus and neonate. Infection also occurs in immunosuppressed patients, e.g.…
Immunohistochemistry (IHC)
cMyc protein is a transcription factor localized to the nucleus of the cell. Amplification of the cMyc gene has been found in several types of human tumors. cMyc is amplified in 20-30% of breast cancer cases and is associated with HER-2…
Immunohistochemistry (IHC)
Collagen IV is a major constituent of the basement membranes along with laminins and enactins. In kidney, the antibody reacts with glomerular and tubular basement membranes, parts of the mesenchymal matrix, and the Bowman’s capsule. It also reacts…
Immunohistochemistry (IHC)
Special stain.
Immunohistochemistry (IHC)
Testing is performed by Blueprint Genetics. The Comprehensive Hereditary Cancer Panel includes next-gen sequencing of coding regions, exon-intron boundaries, and certain non-coding variants in 146 genes. Deletion/duplication analysis is performed to…
Molecular
Special stain. Amyloidosis is a rare disease characterized by the deposition of insoluble misfolded proteins in various tissues and organs. Congo red stain is the gold standard for the demonstration of amyloid in tissue sections. The amyloid fibril…
Immunohistochemistry (IHC)
Special stain.
Immunohistochemistry (IHC)
Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenesis, enhancing cell invasiveness, mediating immune suppression, and by increasing the production of…
Immunohistochemistry (IHC)
Inactive cREL resides in the cytoplasm and translocates to the nucleus upon activation. Strong, homogeneous nuclear cREL staining has been observed in primary mediastinal large B-cell lymphoma whereas nuclear cREL expression is more variable in…
Immunohistochemistry (IHC)
Bi-directional sequencing of exons 14 and 17 of the CSF3R gene which includes detection of the common mutation T618I (also known as T595I).
Molecular
CTNNB1 mutation analysis is performed by next-generation sequencing of all coding exons of the CTNNB1 gene.
Molecular
CXCL13 is useful marker in the diagnosis of angioimmunoblastic T-cell lymphoma
Immunohistochemistry (IHC)
Bi-directional sequencing to detect nonsense, frameshift, and other mutations encoding the C-terminus of CXCR4. Analyzed range includes detection of the C1013G mutation and spans amino acids L301 to S352. Testing is available separately or in…
Molecular
D2 40 identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Anti-D2 40 has also been demonstrated to label lymphatic endothelium whereas it is unreactive with…
Immunohistochemistry (IHC)
This antibody reacts with a subset of B-cells in the mantle zone and some immunoblasts outside the follicle. It reacts with most hairy cell leukemia cases. This antibody shows strong positive staining in some high grade B-cell lymphoma cases.
Immunohistochemistry (IHC)